Mpox and People with HIV

Content From: HIV.govUpdated: November 7, 20234 min read


Spread the word about the Mpox vaccine to get infections to zero and keep them that way.

Mpox and HIV: What’s the Connection?

Mpox is a disease caused by infection with the mpox virus. It can spread through close, personal, often skin-to-skin contact with someone who has mpox. While anyone can get mpox, CDC research shows that about 40% of people diagnosed with mpox in the United States also have HIV.

Also, people with advanced or untreated HIV (those who are immunocompromised) may experience more severe illness or even death if they get the mpox virus.

It’s important to know about how mpox spreads, how to protect yourself and others, and how to treat it if you get it. Watch the videos below to get the facts.

Isn’t Mpox Over?

Use the Locator to find an mpox vaccine near you.

The mpox national public health emergency ended on January 31, 2023, but that doesn’t mean the virus is completely gone. Vaccination is an important tool in preventing the spread of mpox beyond an outbreak.

CDC recommends that the following individuals get vaccinated with both doses of the mpox vaccine:

  • Gay, bisexual, and other men who have sex with men, transgender, or nonbinary people who in the past 6 months have had one of the following:
    • A new diagnosis of ≥1 sexually transmitted disease
    • More than one sex partner
    • Sex at a commercial sex venue
    • Sex in association with a large public event in a geographic area where mpox transmission is occurring.
  • Sexual partners of persons with the risks described above.
  • Persons who anticipate experiencing any of the above.

Also, there continue to be populations experiencing mpox vaccination disparities, such as Black/African American and Hispanic/Latino gay, bisexual, and other men who have sex with men. Read the Mpox Equity Toolkit to learn how you can be involved in efforts to deliver vaccine information and other key details to populations most affected by mpox.

Learn About the Mpox Vaccine

Please download and share these videos on your social media channels. Los videos están disponibles en español.


Get the Facts About Mpox and HIV

Looking for more information about mpox? It’s important to separate myths from facts.

Visit CDC’s mpox site for the latest information about mpox symptoms, how it spreads, prevention, vaccines, treatment, and more.

Read CDC’s FAQ about mpox and HIV.

Fact sheets:

Help others locate mpox vaccines: Embed CDC’s mpox vaccine locator on your site and register your eligible organization to be included in search results.