Syphilis and People with HIV

Content From: CDC.govUpdated: January 26, 20245 min read


Having syphilis can increase your chances of getting or transmitting HIV. Talk to a provider about syphilis prevention, testing, and treatment.

HIV and Syphilis: What’s the Connection?

Syphilis is a sexually transmitted infection* (STI) caused by a type of bacteria. Cases of syphilis have been increasing in the U.S., especially among gay, bisexual, and other men who have sex with men (MSM). In fact, a CDC report showed that U.S. syphilis cases rose 32% from 2020-2021.

According to CDC, approximately half of MSM with primary and secondary (P&S) syphilis (the most infectious stages of syphilis) also have HIV. And MSM who are HIV-negative and diagnosed with P&S syphilis are more likely to get HIV.

Having a syphilis sore may make it easier for HIV to enter your body. And having HIV and another STI may also increase the risk of HIV transmission.

Syphilis is treatable and curable. However, having HIV can make syphilis harder to treat, especially if you have advanced or untreated HIV. If you have both HIV and syphilis, it’s important to take your HIV medicine as directed and take a full cycle of medication to cure the syphilis.

How Is Syphilis Spread?

Syphilis can be transmitted during anal, vaginal, and oral sex without a condom with a partner who has syphilis. Any sexually active person can get it.

Syphilis is passed from person to person through direct contact with a syphilis sore. Because syphilis sores can be painless and hidden in the vagina, anus, under the foreskin of the penis, or in the mouth, it is possible to have syphilis sores and not know it.

If you are pregnant and have untreated syphilis, it can be passed to the baby during pregnancy or birth. This is called congenital syphilis, and it can lead to poor birth outcomes, including birth defects and infant death.

You can NOT get syphilis through casual contact with objects such as toilet seats, doorknobs, swimming pools, hot tubs, bathtubs, shared clothing, or eating utensils.

How Can You Know If You Have Syphilis?

Syphilis infection develops in stages (primary, secondary, latent, and tertiary). Each stage has different signs and symptoms. Read this information from CDC about signs and symptoms during each of the stages.

However, many people with syphilis do not have symptoms or do not notice them. The only way to know is to get tested.

Getting Tested for Syphilis

If you are sexually active, talk openly with a health care provider about your sexual history and ask whether you should be tested for syphilis or other STIs. If you don’t have a provider, use the Locator to find an STI testing and treatment site near you.

According to CDC, you should get tested regularly for syphilis if you are sexually active and

In addition, all pregnant people should receive syphilis testing at their first prenatal visit. Some pregnant people need to receive syphilis testing again during the third trimester at 28 weeks and at delivery.

The testing process: Most of the time, health care providers will use a blood test to test for syphilis. If you have open sores, a provider may swab the area to take a sample of fluid and test it. As required by the Affordable Care Act, most health plans must cover syphilis testing at no cost to you.

Telling your partner(s): If you have syphilis, it is important to tell your sexual partner(s), if it is safe to do so, for their own health and to prevent you from getting syphilis again. Your local health department may offer partner services—a free service to help locate and inform your partner(s) of their potential exposure and provide them with testing, counseling, and linkage to care. Ask your testing site about partner services or call your health department.

Questions for your health care provider: Consider taking this list of questions when you go to get tested.

How Can You Prevent Syphilis?

Using condoms the right way every time is the best way to prevent syphilis and many other STIs.

Condoms protect against syphilis by preventing contact with a sore. However, there may be sores outside the area covered by a condom. Contact with these sores can still transmit syphilis.

If you are sexually active, you can also avoid syphilis by being in a long-term mutually monogamous relationship with a partner who has been tested and does not have syphilis.

The only way to completely avoid getting syphilis and other STIs is to not have vaginal, anal, or oral sex.

Can Syphilis Be Cured?

Yes. When diagnosed early, syphilis can be cured with appropriate antibiotics prescribed by a health care provider. However, treatment might not undo any damage the infection has already done. Also, due to increased demand, the U.S. is currently experiencing a shortage of the type of penicillin used to treat syphilis.

Having syphilis once does not protect you from getting it again. Even after successful treatment, you can get syphilis again.

If left untreated, syphilis can lead to very serious health problems, such as tumors; blindness; paralysis; and damage to the nervous system, brain, and other organs.

STI National Strategic Plan

STI National Strategic Plan 2021-2025 Cover

The U.S. Department of Health and Human Services (HHS) released the first-ever STI National Strategic Plan (STI Plan) in December 2020, providing a road map for STI prevention, diagnosis, care, and treatment.

In June 2023, HHS released the STI Federal Implementation Plan, a companion document outlining federal actions to reduce the burden of sexually transmitted infections in the United States through 2025.

Learn More

Learn more by visiting CDC’s Syphilis Facts and Brochures. There, you’ll find basic and detailed fact sheets about syphilis, information about syphilis and MSM, information about congenital syphilis, and links to other CDC resources.

* The terms STI and STD: The term sexually transmitted infection (STI) refers to a virus, bacteria, fungus, or parasite that is passed from person to person through sexual contact. A sexually transmitted disease (STD) is a disease that develops from an STI. Some people use both terms. Many health organizations – including – are using the term STI more often, except when referring to data or information from sources that use STD.