Ready, Set, PrEP is a nationwide program that provides PrEP medications at no cost to individuals who qualify. To check eligibility and enroll in the program click here.
What is PrEP?
PrEP, or pre-exposure prophylaxis, is an HIV prevention method in which people who don’t have HIV take HIV medicine to reduce their risk of getting HIV if they are exposed to the virus. PrEP can stop HIV from taking hold and spreading throughout your body. Currently, there are only two FDA-approved daily oral medications for PrEP.
PrEP is prescribed to HIV-negative adults and adolescents who are at high risk for getting HIV through sex or injection drug use.
Why Take PrEP?
PrEP is highly effective when taken as indicated.
The once-daily pill reduces the risk of getting HIV from sex by more than 90%. Among people who inject drugs, it reduces the risk by more than 70%.
Your risk of getting HIV from sex can be even lower if you combine PrEP with condoms and other prevention methods.
Is PrEP Right for You?
PrEP may benefit you if you are HIV-negative, you have had anal or vaginal sex in the past 6 months, and you:
- have a sexual partner with HIV (especially if the partner has an unknown or detectable viral load),
- have not consistently used a condom, or
- have been diagnosed with an STD in the past 6 months.
PrEP is also recommended for people who inject drugs and have an injection partner with HIV, or who share needles, syringes, or other injection equipment.
It may be right for you if you’ve been prescribed PEP (post-exposure prophylaxis) and you report continued risk behavior or have used multiple courses of PEP.
If you are a woman and have a partner with HIV and are considering getting pregnant, talk to your doctor about PrEP. PrEP may be an option to help protect you and your baby from getting HIV while you try to get pregnant, during pregnancy, or while breastfeeding.
What Drugs Are Approved for PrEP?
Currently, there are only two medications approved for daily use as PrEP. Both are combinations of two anti-HIV drugs in a single pill:
- Emtricitabine (F) 200 mg in combination with tenofovir disoproxil fumarate (TDF) 300 mg (F-TDF; brand name Truvada®) is recommended for all adults and adolescents at risk for HIV through sex or injection drug use.
- Emtricitabine (F) 200 mg in combination with tenofovir alafenamide (TAF) 25 mg (F-TAF; brand name Descovy®) is recommended for adults and adolescents at risk for HIV through sex, excluding people at risk through vaginal sex. Descovy® has not yet been studied for HIV prevention for receptive vaginal sex.
Is PrEP Safe?
PrEP is safe. No significant health effects have been seen in people who are HIV-negative and have taken PrEP for up to 5 years.
Some people taking PrEP may have side effects, like nausea, but these side effects are usually not serious and go away over time. If you are taking PrEP, tell your health care provider if you have any side effect that bothers you or that does not go away.
And be aware: PrEP protects you against HIV but not against other sexually transmitted infections (STIs) or other types of infections. Combining PrEP with condoms will reduce your risk of getting other STIs.
How Do You Get PrEP?
If you think PrEP may be right for you, visit your doctor or health care provider. PrEP is only available by prescription. Any health care provider licensed to write prescriptions can prescribe PrEP; specialization in infectious diseases or HIV medicine is not required.
If you don’t have a doctor, you can use the HIV Services Locator to find a PrEP provider and other HIV services near you. You can visit many community health centers for a PrEP consultation. More than 190 health centers in the 57 jurisdictions prioritized in the Ending the HIV Epidemic initiative are providing PrEP services. Many health centers in other jurisdictions also provide PrEP services.
Because PrEP is for people who are HIV-negative, you’ll have to get an HIV test before starting PrEP and you may need to get other tests to make sure it’s safe for you to use PrEP.
If you take PrEP, you’ll need to see your healthcare provider every 3 months for repeat HIV tests, prescription refills, and follow-up.
PrEP and COVID-19
There are options for starting or continuing PrEP while COVID-19 precautions are in effect. Some clinics and health care providers offer self-testing kits so that you can safely take HIV tests at home as part of your ongoing PrEP care. Others offer telehealth appointments or 90-day prescriptions of PrEP medication to help you minimize your trips to the pharmacy. Talk to your clinic or health care provider’s office about how you can access PrEP.
Find resources about COVID-19 and people with HIV.
How Can You Get Help Paying For PrEP?
As of 2021, most health plans must cover the full cost of PrEP medications without charging you a co-payment due to the covered preventive services provision of the Affordable Care Act. To find out whether your health plan covers PrEP medications without charge:
- If you have private health insurance through your employer or have purchased it yourself, check with your health insurance company about coverage for PrEP medications.
- If you purchase a health plan through HealthCare.gov or a state-based Marketplace, this NASTAD flyer can help you verify whether the plan covers PrEP medications.
- If you are on Medicaid, check with your benefits counsellor.
If you have health insurance that still requires a co-pay, but you can’t afford it, you may receive co-pay assistance from drug manufacturers, state programs, or patient advocacy foundations.
To get or renew a PrEP prescription, there are also costs of clinic visits and lab tests. If these services are not covered by your health plan:
- You can get them at HRSA-funded Health Centers, where the sliding scale fees are based on your ability to pay. There are more than 12,000 health centers nationwide.
- Some state PrEP assistance programs cover clinical visits and labs.
If you don’t have insurance, your health care provider can direct you to medication assistance programs for PrEP, or a patient navigator or benefits counsellor at your clinic or provider’s office can help you enroll in a Marketplace plan or Medicaid, if you are eligible. You may also qualify for Ready, Set, PrEP (see the blue box).
If you don't have prescription drug insurance, you may be eligible for Ready, Set, PrEP , a national program that makes PrEP medications available at no cost.
To qualify for Ready, Set, PrEP, you must test negative for HIV, have a valid prescription for the medication, and not have prescription drug coverage. All medications are fully covered for qualifying participants; however, the costs of necessary clinic visits and lab tests may vary depending on a person’s income.
To find out if you qualify, visit GetYourPrEP.com or call toll-free 855-447-8410.
View this CDC fact sheet on paying for PrEP.
Learn More About PrEP
If you think PrEP might be right for you, or you want to learn more visit CDC’s PrEP Basics.
Use the HIV Services Locator to find a PrEP provider and other HIV services near you.